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Actin' Up to Stop SNFin Out TEAD
Andrea I McClatchey1, Katia Georgopoulos1
1MGH Center for Cancer Research and Cutaneous Biology Research Center, Charlestown, MA 02129, USA.
Developmental Cell
|December 19, 2018
Abstract:
The transcriptional activators YAP and TAZ integrate mechanical and biochemical signals to support growth and regeneration. A recent study in Nature (Chang et al., 2018) showed that SWI/SNF sequesters YAP from its DNA-binding partner TEAD. Mechanical coupling between cytoskeleton and nucleus reverses this antagonism by nuclear F-actin sequestering of SWI/SNF.