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Updated: Jan 31, 2026

Large-Scale Screens of Metagenomic Libraries
Published on: May 28, 2007
An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer -
Markus Follmann1, Hans Briem2, Andreas Steinmeyer2
1Bayer AG, Pharmaceuticals, Aprather Weg 18a, 42113 Wuppertal, Germany.
Abstract:
Pharmaceutical companies often refer to 'screening their library' when performing high-throughput screening (HTS) on a corporate compound collection to identify lead structures for small-molecule drug discovery programs. Characteristics of such a library, including the size, chemical space covered, and physicochemical properties, often determine the success of a screening campaign. Therefore, strategies to maintain and enhance the overall quality of screening collections are crucial to stay competitive and to cope with the 'novelty erosion' that is observed gradually. The Next Generation Library Initiative (NGLI), the enhancement of Bayer's HTS collection by 500000 newly designed compounds within 5 years, is addressing exactly this challenge. Here, we describe this collaborative project, which involves all internal medicinal chemists in a crowd-sourcing approach, as well as selected external partners, to reach this ambitious goal.
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