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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Jan 31, 2026

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
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Peripheral neuropathies and aging.

Marion Brisset1, Guillaume Nicolas1

  • 1Service de neurologie, Hôpital Raymond Poincaré, Garches, France.

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|December 20, 2018
PubMed
Summary

Neuropathies are common in older adults, affecting about 7% of those over 65. This review highlights specific clinical and electrophysiological features of neuropathies in the elderly, emphasizing the need to rule out treatable causes.

Keywords:
Charcot Marie Toothagingchronic inflammatory demyelinating polyneuropathyhereditary neuropathiesneuropathiespolyneuropathiessmall fibers neuropathies

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Area of Science:

  • Neurology
  • Geriatrics

Background:

  • Neuropathies are highly prevalent in individuals over 65, with prevalence increasing with age.
  • Polyneuropathies affect approximately 7% of the elderly population.
  • Other forms of neuropathy require consideration beyond polyneuropathy.

Purpose of the Study:

  • To review various forms of neuropathy in the elderly.
  • To emphasize the unique clinical and electrophysiological characteristics of neuropathies in this age group.
  • To guide diagnostic approaches in elderly patients with suspected neuropathy.

Main Methods:

  • Literature review focusing on neuropathies in the elderly.
  • Analysis of clinical presentations and electrophysiological findings.
  • Discussion of differential diagnoses relevant to aging populations.

Main Results:

  • Diabetes mellitus is a leading global cause of neuropathy.
  • In individuals over 80, idiopathic neuropathy accounts for about 40% of cases after initial investigations.
  • Essential to exclude vitamin deficiencies, dysimmune, and hereditary causes, considering age-related factors.

Conclusions:

  • Neuropathies present distinct features in the elderly.
  • Thorough initial investigations are crucial to identify treatable etiologies.
  • Age-specific considerations are vital for accurate diagnosis and management of neuropathy in older adults.