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Schemas

Schemas

A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.

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Lipedema-An update.

¹Department of Dermatology and Allergology, Academic Teaching Hospital Dresden, Dresden, Germany.

Dermatologic Therapy

|December 20, 2018

Summary

This summary is machine-generated.

Lipedema is a chronic condition affecting subcutaneous fat in females, causing limb swelling and pain. Recent advancements offer new insights into its understanding and treatment.

Keywords:

bruising complex decongestive therapy edema lipedema liposuction lymphedema obesity pain subcutaneous adipose tissue

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Area of Science:

Medical Science
Endocrinology
Genetics

Background:

Lipedema is a chronic, debilitating condition affecting subcutaneous adipose tissue in the extremities of females, typically manifesting during or after puberty.
Characterized by bilateral swelling, bruising, and pain in the legs and/or arms, lipedema spares the most distal parts, distinguishing it from lymphedema.
Unlike obesity, lipedema patients exhibit a reduced risk of developing diabetes mellitus, suggesting unique pathophysiological mechanisms.

Purpose of the Study:

To review recent advancements in the understanding of lipedema pathogenesis.
To summarize current and emerging treatment strategies for lipedema.
To highlight the role of hormonal factors in the exclusively female presentation of lipedema.

Main Methods:

Literature review of recent studies on lipedema.
Analysis of current research on lipedema pathogenesis and contributing factors.
Synthesis of information on established and novel therapeutic approaches.

Main Results:

The pathogenesis of lipedema remains incompletely understood, but hormonal influences are strongly implicated due to its exclusive occurrence in females.
Key characteristics include disproportionate fat distribution, pain, and easy bruising, with significant impact on quality of life.
Recent research has focused on genetic predispositions, inflammatory processes, and the role of adipose tissue dysfunction.

Conclusions:

Lipedema is a distinct disease entity requiring specific diagnostic and management strategies.
Further research into its pathophysiology is crucial for developing targeted therapies.
Current treatment focuses on symptom management, including conservative measures and surgical options, with ongoing investigations into novel pharmacological interventions.