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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Relative Risk01:12

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Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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Transcription Factors02:16

Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Factors Affecting Solubility04:01

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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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Transcription Elongation Factors02:35

Transcription Elongation Factors

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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
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Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Psoriasis risk factors and triggers.

Erica B Lee1, Kevin K Wu2, Michael P Lee3

  • 1University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA.

Cutis
|December 20, 2018
PubMed
Summary

Psoriasis onset and worsening are influenced by genetic factors like HLA-Cw6 and CARD14 gene mutations, alongside environmental triggers such as infections and lifestyle choices. Understanding these psoriasis risk factors aids in comprehending disease pathogenesis and patient education.

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Area of Science:

  • Dermatology and Immunology
  • Genetics and Molecular Biology

Background:

  • Psoriasis is a chronic inflammatory skin condition with complex etiology.
  • Both inherited and external factors play significant roles in its development and progression.

Purpose of the Study:

  • To summarize the known genetic and environmental risk factors contributing to psoriasis.
  • To emphasize the clinical importance of recognizing these triggers for patient management and understanding disease mechanisms.

Main Methods:

  • Review of existing literature on psoriasis genetics and environmental influences.
  • Synthesis of data on specific genetic markers and common environmental triggers.

Main Results:

  • Identified key genetic risk factors including HLA-Cw6 and CARD14 gene mutations.
  • Highlighted environmental contributors such as infections, medications, and lifestyle factors.
  • Established the link between these factors and psoriasis pathogenesis.

Conclusions:

  • Awareness of genetic and environmental risk factors is crucial for clinicians treating psoriasis.
  • Understanding triggers can improve patient education and disease management strategies.
  • Further research into the interplay of these factors may reveal new therapeutic targets.