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Related Experiment Video

Updated: Jan 31, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Imatinib and liver toxicity.

Mohammad Inamul Haq¹, Joanna Nixon², Adrian J Stanley¹

¹Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK.

BMJ Case Reports

|December 21, 2018

Summary

Imatinib treatment for gastrointestinal stromal tumors can cause severe liver injury. Steroid treatment and drug discontinuation rapidly improved liver function in a patient with no prior liver disease risk factors.

Keywords:

chemotherapy gastric cancer liver disease

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Area of Science:

Hepatology
Oncology
Pharmacology

Background:

Imatinib is a tyrosine kinase inhibitor used for gastrointestinal stromal tumors (GIST) and chronic myeloid leukemia.
Hepatotoxicity is a known adverse effect of imatinib, ranging from abnormal liver function tests to acute liver failure.
Chronic hepatitis B reactivation is also associated with imatinib therapy.

Observation:

A patient with a resected jejunal GIST received adjuvant imatinib therapy.
The patient developed severe hepatotoxicity without pre-existing liver disease risk factors.
Hepatotoxicity resolved dramatically after imatinib discontinuation and initiation of steroid treatment.

Findings:

The case highlights severe imatinib-induced hepatotoxicity in a patient with GIST.
Causality was strongly suggested by the temporal relationship and resolution upon drug withdrawal.
Liver biopsy was deferred due to rapid clinical improvement with steroids.

Implications:

Clinicians should monitor liver function closely in patients receiving imatinib, especially for GIST.
Prompt recognition and management of imatinib-induced hepatotoxicity are crucial.
Steroid therapy may be effective in managing severe imatinib-related liver injury.