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Updated: Jan 31, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
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A Neuroendocrine Tumor of Unknown Primary Origin that Responded to Treatment Based on Tumor Grade Progression

Yukako Hamano1, Toshikazu Moriwaki1, Keii To1

  • 1Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.

Internal Medicine (Tokyo, Japan)
|December 21, 2018
PubMed

Insights

Neuroendocrine tumors (NETs) initially treated with somatostatin analogs (SSAs) can progress to neuroendocrine carcinoma (NEC). Platinum-based chemotherapy effectively treated a patient's NEC after SSA failure, demonstrating a successful treatment shift.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Standard treatments for neuroendocrine tumors (NETs) include somatostatin analogs (SSAs) for G1/G2 NETs and platinum-based chemotherapy for neuroendocrine carcinoma (NEC).
  • Accurate classification of NETs is crucial for determining appropriate therapeutic strategies.

Observation:

  • A 46-year-old male patient with metastatic NET G2 showed initial stability with SSA treatment for one year.
  • Tumor progression was observed, and a subsequent biopsy revealed a transformation to neuroendocrine carcinoma (NEC).

Findings:

  • The patient received platinum-based chemotherapy (cisplatin plus etoposide) following the NEC diagnosis.
  • Significant tumor size reduction was achieved with the platinum-containing chemotherapy regimen.

Implications:

  • This case highlights the potential for NETs to dedifferentiate into NEC and the efficacy of platinum-based chemotherapy in such advanced cases.
  • It suggests a potential treatment pathway for patients with advanced NETs that progress despite SSA therapy.
Keywords:
NET G3biopsychemotherapyneuroendocrine tumorsomatostatin analog

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