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Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

Coagulation

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

Thermal expansion and Thermal stress: Problem Solving

Thermal expansion and Thermal stress: Problem Solving

San Francisco's Golden Gate Bridge is exposed to temperatures ranging from -15 °C to 40 °C. At its coldest, the main span of the bridge is 1275 m long. Assuming that the bridge is made entirely of steel, what is the change in its length between these temperatures?
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...

Thermal Strain

Thermal Strain

Thermal strain is a concept that arises when we consider how temperature changes affect structures. Unlike the conventional assumption that structures remain constant under load, real-world scenarios often involve temperature fluctuations that can significantly impact these structures. Consider a homogeneous rod with a uniform cross-section resting freely on a flat horizontal surface. If the rod's temperature increases, the rod elongates. This elongation is proportional to the temperature...

Thermal Expansion

Thermal Expansion

The expansion of alcohol in a thermometer is one of many commonly encountered examples of thermal expansion, which is the change in size or volume of a given system as its temperature changes. The most visible example is the expansion of hot air. When air is heated, it expands and becomes less dense than the surrounding air, which then exerts an upward force on the hot air to, for example, make steam and smoke rise, and hot air balloons float. The same behavior happens in all liquids and gases,...

Thermal Stress

Thermal Stress

If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...

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Related Experiment Video

Updated: Jan 31, 2026

Thermal Measurement Techniques in Analytical Microfluidic Devices

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

Thermal Coagulation Device for Treating Cervical Dysplasia.

Ashley Langell¹, Timothy Pickett¹, Catherine Mangum¹

¹1 University of Utah, Salt Lake City, UT, USA.

Surgical Innovation

|December 21, 2018

Summary

A low-cost, portable thermal coagulation device was developed to treat cervical intraepithelial neoplasia (CIN) in resource-limited settings, addressing a critical global health need for cervical cancer prevention.

Keywords:

biomedical engineering ergonomics and/or human factors study the business of surgery

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Last Updated: Jan 31, 2026

Thermal Measurement Techniques in Analytical Microfluidic Devices

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Published on: June 3, 2015

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

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A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

Published on: February 7, 2022

Area of Science:

Biomedical Engineering
Global Health
Medical Technology Innovation

Background:

Cervical cancer is a leading cause of preventable death, particularly in developing regions with limited healthcare access.
Resource constraints in developing areas hinder effective cervical cancer prevention strategies.
Cervical intraepithelial neoplasia (CIN) is a precursor to cervical cancer, necessitating accessible treatment options.

Purpose of the Study:

To develop a low-cost, portable medical technology for treating cervical intraepithelial neoplasia (CIN).
To address the unique challenges of cervical cancer prevention in resource-limited global settings.
To create a heat ablation device utilizing thermal coagulation for CIN treatment.

Main Methods:

A multidisciplinary student team collaborated with clinical and industry advisors.
Employed a systematic approach including problem validation and user-centered design.
Focused on developing a globally applicable treatment for CIN, including business planning and regulatory clearance.

Main Results:

A functional, self-contained, battery-operated prototype was developed in 72 days.
The finalized medical device received Food and Drug Administration (FDA) clearance within 18 months.
The technology offers a portable and accessible solution for CIN treatment.

Conclusions:

Interdisciplinary university programs can accelerate medical technology development.
Academic-industry partnerships are crucial for commercializing affordable global health solutions.
This project demonstrates a successful model for addressing critical global health issues through innovative medical technology.