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Updated: Jan 31, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Engineering Bacteriophage-Based Biosensors.

Daniel Brownell¹, John King¹, Brian Caliando¹

¹Sample 6 Technologies, 15300 Bothell Way NE Lake Forest Park, WA, 98155, Woburn, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|December 21, 2018

Summary

This summary is machine-generated.

Advanced bacteriophage engineering methods now enable broader applications in diagnostics. These new techniques allow for modular and rapid genome modifications, expanding phage diagnostic capabilities.

Keywords:

Bacteriophage engineering Diagnostics Genome engineering Luciferase Reporter systems

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Area of Science:

Microbiology
Molecular Biology
Biotechnology

Background:

Bacteriophages have historical diagnostic applications.
Previous engineering limitations restricted phage diagnostics to specific settings.
Recent advances in DNA sequencing and reporter systems are enabling new phage engineering approaches.

Purpose of the Study:

To describe advanced methods for bacteriophage genome engineering.
To enable modular and rapid engineering of bacteriophage genomes.
To broaden the scope of modern phage diagnostics.

Main Methods:

Development of novel engineering strategies for bacteriophage genomes.
Utilizing advances in DNA sequencing technologies.
Incorporation of sensitive reporter systems for phage modification.

Main Results:

Demonstration of advanced, modular, and rapid bacteriophage genome engineering.
Expansion of the toolkit for creating engineered bacteriophages.
Facilitation of new diagnostic applications using modified bacteriophages.

Conclusions:

Modern bacteriophage diagnostics benefit from advanced engineering methods.
Modular and rapid genome engineering enhances bacteriophage utility.
Engineered bacteriophages hold significant potential for diverse diagnostic settings.