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Related Experiment Video

Updated: Jan 31, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

YAPping about and not forgetting TAZ.

Bernard A Callus¹, Megan L Finch-Edmondson^2,3, Sue Fletcher^1,4

¹Centre for Comparative Genomics, Murdoch University, Australia.

|December 21, 2018

Summary

This summary is machine-generated.

The Hippo pathway regulates growth and development through key proteins YES-associated protein (YAP) and TAZ. This review details their functions, interactions, and regulatory mechanisms in various biological processes.

Keywords:

Hippo signalling cancer cellular localization functional regulation gene transcription phosphodegron protein-protein interaction stability transcriptional coactivator with PDZ-binding motif yes-associated protein

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Area of Science:

Molecular Biology
Cellular Signaling
Developmental Biology

Background:

The Hippo pathway is a crucial eukaryotic signaling network.
YES-associated protein (YAP) and TAZ are key transcriptional coactivators in Hippo signaling.
These proteins regulate vital processes like organ growth, stem cell function, and cancer development.

Purpose of the Study:

To provide an overview of the Hippo signaling pathway and its role in organismal growth.
To discuss the functional domains and regulatory mechanisms of YAP and TAZ.
To highlight the similarities and differences between YAP and TAZ in their interactions and activities.

Main Methods:

Literature review of Hippo pathway research.
Analysis of YAP and TAZ protein structure and function.
Comparison of YAP and TAZ interaction partners and regulatory networks.

Main Results:

YAP and TAZ are multidomain proteins acting as transcriptional coactivators.
Their activity is modulated by complex regulatory processes affecting protein stability and localization.
Specific functional domains of YAP and TAZ mediate interactions with diverse partner proteins.

Conclusions:

The Hippo pathway, via YAP and TAZ, plays a central role in controlling cell proliferation and tissue homeostasis.
Understanding YAP and TAZ regulation is critical for insights into development, regeneration, and disease.
Detailed comparison of YAP and TAZ reveals nuanced roles in mediating biological outcomes.