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Updated: Jan 31, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
In-vitro study of species-specific coagulation differences in animals and humans using rotational thromboelastometry
Raimund Lechner1, M Helm2, M Müller3
1Department of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Medicine, German Armed Forces Hospital of Ulm, Ulm, Germany raimundedgarlechner@bundeswehr.org.
Abstract:
Animal tests are conducted in all fields of trauma research, but transferability of these data to humans is limited. For example, it is still unclear which animal species is most similar to humans in terms of physiology of blood coagulation. To improve transferability and raise awareness of the existing differences, we compared human coagulation to coagulation of different animals. Rotational thromboelastometry was used to analyse the blood of pigs, sheep, rabbits and dogs. Animal data were compared with human coagulation based on the number of significant differences of the test parameters and on a descriptive comparison of the extent of relative deviation of the single values. All animal species showed significant differences in coagulation properties when compared with humans. Coagulation parameters of dogs and sheep were on average most similar to humans. However, there is no animal which is most similar to humans concerning all aspects of coagulation. Differences in coagulation between humans and animals are significant. This must be taken into account when transferring animal test data to humans.
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