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Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine.
X Michelle Androulakis1,2, Kaitlin A Krebs1, Charmaine Jenkins1
1Division of Neurology, WJB Dorn VA Medical Center, Columbia, SC, USA.
Journal of Neurological Disorders
|December 22, 2018
Summary
Chronic migraine (CM) shows decreased brain network connectivity, particularly in the Central Executive Network (CEN). Medication overuse headache (MOH) in CM leads to more widespread disruptions in these networks.
Area of Science:
- Neuroscience
- Neurology
- Radiology
Background:
- Chronic migraine (CM) mechanisms are poorly understood, but linked to reduced intrinsic brain network connectivity.
- Investigating neural network alterations is crucial for understanding CM pathophysiology.
Purpose of the Study:
- To analyze functional connectivity within the Central Executive Network (CEN) and Default Mode Network (DMN) in chronic migraine (CM).
- To compare CM patients with and without medication overuse headache (MOH) to healthy controls.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used to assess node-to-node functional connectivity (NTNC).
- Analysis included 136 CEN NTNC pairs and 6 DMN NTNC pairs in CM (n=13), CM with MOH (CMMOH, n=16), and controls.
Main Results:
- Both CM and CMMOH groups exhibited decreased CEN connectivity, including between prefrontal cortex (PFC) regions and the anterior thalamus.
- CMMOH showed more widespread CEN disruptions than CM when compared to controls.
- Specific decreased connectivity within the CEN (right inferior frontal gyrus to left dorsolateral PFC) was noted in CMMOH compared to CM.
Conclusions:
- Similar patterns of CEN connectivity dysfunction exist in CM, irrespective of MOH status.
- Medication overuse headache exacerbates intranetwork disruptions within the CEN in chronic migraine patients.
- Altered connectivity in CM may relate to impaired cognitive control and pain regulation, with more severe deficits in CMMOH.
Keywords:
Central executive networkChronic migraineDefault mode networkFunctional MRIMedication overuse headacheMore Related Videos
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