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Updated: Jan 31, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Multicomponent synthesis of pyroglutamic acid derivatives via
Tushar M Khopade1, Prakash K Warghude, Amol D Sonawane
1Department of Chemistry, Indian Institute of Science Education and Research (IISER)-Pune, Dr Homi Bhabha Road, Pashan, 411008, Pune, Maharashtra, India. rgb@iiserpune.ac.in.
Abstract:
A novel and practical method for the synthesis of 3-substituted pyroglutamic acid derivatives is described. One pot multicomponent reaction of Meldrum's acid, aldehyde and Schiff's base followed an unprecedented chemoselective Knoevenagel-Michael-hydrolysis-lactamization domino sequence to afford 4-carboxy 3-substituted pyroglutamic acid derivatives under mild conditions. A carboxy intermediate formed appears to accelerate its own formation. The generality of the synthesis is exemplified by the use of a wide variety of aldehydes including enolizable aliphatic aldehydes, while substrates are stable under reaction conditions.
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