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Senescent fibroblasts in melasma pathophysiology

Misun Kim1, So Min Kim1, Soohyun Kwon1

  • 1Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Experimental Dermatology
|December 22, 2018
PubMed

Insights

Melasma may involve senescent fibroblasts, identified by p16INK4A. Radiofrequency therapy reduced these cells and pigmentation, suggesting senescent fibroblasts as a potential melasma treatment target.

Area of Science:

  • Dermatology
  • Cell Biology
  • Aging Research

Background:

  • Melasma is proposed as a photoaging skin disorder.
  • Photoaged fibroblasts may influence skin pigmentation through melanogenic factors.

Purpose of the Study:

  • To investigate the presence of senescent cells in melasma.
  • To explore the therapeutic potential of targeting senescent fibroblasts in melasma.

Main Methods:

  • Assessed p16INK4A (a cell senescence marker) in lesional and perilesional skin from 38 melasma patients.
  • Conducted a pilot study using radiofrequency (RF) intervention for melasma.

Main Results:

  • Lesional dermal skin showed significantly more p16INK4A-positive senescent cells than perilesional skin.
  • RF therapy decreased senescent cell count and increased procollagen-1 expression.
  • Reduced epidermal pigmentation was observed following RF treatment.

Conclusions:

  • Senescent fibroblasts are present in melasma and may contribute to its development.
  • Targeting senescent fibroblasts, potentially via RF therapy, could be a novel therapeutic strategy for melasma.
Keywords:
melasmaphotoageingradiofrequencysenescent fibroblasts

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