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MRI-Compatible Injection System for Magnetic Microparticle Embolization.

Ning Li, Francois Michaud, Zeynab Nosrati

IEEE Transactions on Bio-Medical Engineering

|December 22, 2018

Summary

This summary is machine-generated.

A novel MRI-compatible injector system precisely forms and injects magnetic drug-eluting beads (MDEBs) for targeted intra-arterial therapies. This system overcomes challenges posed by strong clinical MRI magnetic fields, enabling controlled MDEB delivery in embolization procedures.

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Simple and Effective Administration and Visualization of Microparticles in the Circulatory System of Small Fishes Using Kidney Injection

Simple and Effective Administration and Visualization of Microparticles in the Circulatory System of Small Fishes Using Kidney Injection

Published on: June 17, 2018

Area of Science:

Biomedical Engineering
Medical Imaging
Nanotechnology

Background:

Magnetic drug-eluting beads (MDEBs) offer targeted intra-arterial therapies by utilizing magnetic fields.
Clinical 1.5-T and 3-T MRI scanners' strong magnetic fields pose challenges for MDEB aggregate formation and controlled injection.

Purpose of the Study:

To develop and validate an MRI-compatible injector system for precise MDEB aggregate formation and delivery.
To overcome the limitations of strong magnetic fields in clinical MRI for targeted therapies.

Main Methods:

The injector system integrates peristaltic pumps, an optical counter, and a magnetic trap.
Optimization involved studying microparticle magnetic properties, injector component compatibility, and MRI field distribution.
Performance was assessed using biocompatible magnetic microparticles (230 ± 35 μm) suitable for adult trans-arterial chemoembolization.

Main Results:

The system forms MDEB aggregates of 20-60 microparticles with a precision of six particles (1.6–3.2 mm length).
In phantom studies mimicking physiological conditions, 82% of injected MRI-visible MDEB boluses successfully reached target subbranches.

Conclusions:

The developed injector operates effectively within a 3-T MRI environment, forming and automatically injecting MDEB aggregates.
This versatile system is suitable for selective MDEB injections during MR-guided embolization procedures.