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OSCAR: A Modular Open-Source Robotic Platform for Biological Laboratories.

David Pivin1, Antoine Champie2, Mirco Plante3

  • 1Département de génie électrique et génie informatique, Université de Sherbrooke, Sherbrooke, Quebec J1K 2R1, Canada.

ACS Synthetic Biology
|March 9, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed the Open-Source Collaborative Automation & Robotics (OSCAR) platform for affordable laboratory automation. This flexible, low-cost system uses standard equipment to perform complex biological research tasks, democratizing access to scientific tools.

Keywords:
DNA cloningcollaborative roboticslaboratory automationmolecular biologyopen-source platformtask planning

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Area of Science:

  • Biotechnology
  • Robotics in Life Sciences
  • Laboratory Automation

Background:

  • Biological research requires complex, repetitive, high-throughput manipulations.
  • Current robotic systems are often expensive, inflexible, and limited to specific tasks.
  • Proprietary modules and reagents in existing systems hinder accessibility.

Purpose of the Study:

  • To develop a flexible, low-cost automation platform for common laboratory manipulations.
  • To address the limitations of current expensive and inflexible robotic systems.
  • To create an open-source system compatible with standard laboratory equipment and consumables.

Main Methods:

  • Development of the Open-Source Collaborative Automation & Robotics (OSCAR) platform.
  • Integration of open-source software and modular hardware.
  • Equipping a robotic arm with a dual-function end-effector (pipetting module and vision-enabled gripper).
  • Implementation of a representative plasmid assembly workflow.

Main Results:

  • Demonstrated versatility of the OSCAR platform through a complete plasmid assembly workflow.
  • Successful execution of tasks including PCR, enzymatic assembly, transformation, plating, colony picking, PCR screening, and gel electrophoresis.
  • The system proved capable of precise liquid handling and tool manipulation.

Conclusions:

  • The OSCAR platform offers a flexible, affordable, and accessible solution for laboratory automation.
  • Open-source design and compatibility with standard equipment democratize automation in research.
  • Broad adoption of OSCAR can enhance efficiency and accessibility across diverse research environments.