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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
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Doppler Optical Coherence Tomography of Retinal Circulation
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Optical coherence tomography angiography in glaucoma.

Karine D Bojikian1, Philip P Chen, Joanne C Wen

  • 1Department of Ophthalmology, University of Washington, Seattle, Washington, USA.

Current Opinion in Ophthalmology
|December 22, 2018
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography angiography (OCTA) reveals reduced microcirculation in glaucoma patients. This novel imaging technique shows promise for improving glaucoma diagnosis and patient monitoring.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Neuroscience

Background:

  • Glaucoma is characterized by progressive optic nerve damage.
  • Microvascular changes in the optic nerve head and retina are increasingly recognized in glaucoma.
  • Optical coherence tomography angiography (OCTA) offers high-resolution visualization of ocular microcirculation.

Purpose of the Study:

  • To review recent studies utilizing OCTA in glaucoma.
  • To highlight OCTA's potential in diagnosing and monitoring glaucoma patients.
  • To explore the role of microcirculation changes in glaucoma pathogenesis.

Main Methods:

  • Review of recent scientific literature on OCTA in glaucoma.
  • Analysis of studies comparing OCTA findings in glaucoma patients, suspects, and normal individuals.
  • Assessment of OCTA's capability for longitudinal monitoring of vascular changes.

Main Results:

  • OCTA demonstrates reduced microcirculation in the optic nerve head, peripapillary retina, and macula of glaucoma patients.
  • Vascular changes are evident when comparing glaucoma patients to glaucoma suspects and normal eyes.
  • OCTA can detect a progressive decline in vessel density over time in glaucoma patients.

Conclusions:

  • OCTA is a promising new imaging technology for glaucoma research.
  • OCTA has the potential to significantly improve the diagnosis and management of glaucoma.
  • Further research is needed to elucidate the causal relationship between microcirculation and neuronal damage in glaucoma.