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homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum
Ye Ye1, Xing-Wei Yang2, Yan Zhou3
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Abstract:
Hookeriones I-Q (1-9), nine new homo-adamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum hookerianum, along with twenty known analogues. These structures were determined on the basis of comprehensive NMR and MS spectroscopic data. Comprehensive analysis of the NMR data revealed the correlations between the configuration of H-18 and H-28 and the chemical shifts of related signals. The cytotoxicity and anti-allergic activities of the new isolates were evaluated, and several ones exhibited moderate cytotoxicity against ECA-109 cell lines.
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