Related Experiment Video

Updated: Jan 31, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.4K

Temperament in preschool children with sickle cell anaemia

Michelle Downes1,2, Michelle de Haan2, Tess O'Leary1

  • 1School of Psychology, University College Dublin, Dublin, Ireland.

Archives of Disease in Childhood
|December 23, 2018
PubMed

Insights

Preschool children with sickle cell anaemia (SCA) exhibit higher negative affectivity, especially discomfort. This finding highlights the importance of understanding temperament in managing SCA and improving quality of life.

Area of Science:

  • Pediatric Hematology
  • Child Psychology
  • Temperament Research

Background:

  • Limited research exists on the impact of sickle cell anaemia (SCA) on child temperament.
  • Temperament plays a crucial role in childhood development and adaptation.

Purpose of the Study:

  • To investigate temperament characteristics in preschool children diagnosed with SCA.
  • To assess the reliability of the Children's Behaviour Questionnaire (CBQ) for evaluating temperament in children with SCA.

Main Methods:

  • Utilized the Children's Behaviour Questionnaire (CBQ), a parent-report measure.
  • Recruited 21 preschool children with SCA and a matched control group of typically developing children.

Main Results:

  • Children with SCA showed significantly higher negative affectivity compared to controls.
  • Specifically, the discomfort subdomain of negative affectivity was elevated in children with SCA.
  • Higher frequency of hospital admissions correlated with increased reported discomfort.

Conclusions:

  • Preschoolers with SCA demonstrate heightened negative affectivity, particularly discomfort.
  • Further research is needed to explore how emotional dysregulation influences SCA management and long-term quality of life.
Abstract

Keywords:
child psychologyhaematologypainsickle cell diseasetemperament

More Related Videos

Measurement Of Neuromagnetic Brain Function In Pre-school Children With Custom Sized MEG14:15

Measurement Of Neuromagnetic Brain Function In Pre-school Children With Custom Sized MEG

Published on: February 19, 2010

17.3K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.4K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
295
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.1K
What are Cells?01:07

What are Cells?

Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
199.3K
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.4K
Concentration Cells02:41

Concentration Cells

A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
25.9K