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Probiotics in Functional Gastrointestinal Disorders.

Iva Hojsak1,2,3

  • 1Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Zagreb, Croatia. ivahojsak@gmail.com.

Advances in Experimental Medicine and Biology
|December 23, 2018
PubMed
Summary

Probiotics show promise for treating functional gastrointestinal disorders (FGID) in infants and children. Lactobacillus reuteri is effective for infantile colic, with emerging evidence for irritable bowel syndrome and functional abdominal pain.

Keywords:
Functional abdominal painInfantile colicIrritable bowel syndromeLactobacillusProbiotics

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Pediatrics

Background:

  • Functional gastrointestinal disorders (FGID), including infantile colic, constipation, functional abdominal pain (FAP), and irritable bowel syndrome (IBS), are highly prevalent in pediatric populations.
  • The multifactorial etiology of FGID increasingly emphasizes the critical role of the gut microbiota.
  • Modulation of the intestinal microbiota via probiotics presents a potential therapeutic strategy for FGID.

Purpose of the Study:

  • To review the current scientific evidence on the efficacy of probiotics in managing common pediatric FGID.
  • To identify specific probiotic strains and dosages with demonstrated therapeutic effects.

Main Methods:

  • Systematic review of existing clinical studies and scientific literature.
  • Analysis of data focusing on probiotic interventions for infantile colic, FAP, and IBS.
  • Evaluation of evidence strength based on study design, dosage, and specific probiotic strains.

Main Results:

  • Strongest evidence supports Lactobacillus reuteri (L. reuteri) DSM 17938 (10^8 CFU/day) for infantile colic in breastfed infants.
  • Limited but encouraging data suggests efficacy for Lactobacillus rhamnosus GG (LGG) (3x10^9 CFU) and multi-strain probiotics in IBS treatment.
  • Some evidence indicates L. reuteri DSM 17938 (≥10^8 CFU/day) may benefit FAP management.

Conclusions:

  • Probiotics, particularly L. reuteri DSM 17938, demonstrate significant efficacy in treating specific pediatric FGID like infantile colic.
  • Further research is warranted to solidify the role of probiotics in managing IBS and FAP.
  • Targeted probiotic interventions hold promise for improving gut health and managing FGID in children.