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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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High platelet-to-lymphocyte ratio are associated with post-stroke depression
Guiqian Huang1, Huijun Chen1, Qiongzhang Wang1
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
Journal of Affective Disorders
|December 23, 2018
Summary
Elevated platelet-to-lymphocyte ratio (PLR) is a significant predictor of post-stroke depression (PSD). Stratifying PLR levels can enhance the prediction of PSD in acute ischemic stroke patients.
Area of Science:
- Neurology
- Psychiatry
- Biomarkers
Background:
- Post-stroke depression (PSD) is a common complication following stroke.
- Inflammatory cytokines are implicated as risk factors for PSD.
Purpose of the Study:
- To evaluate the predictive value of the platelet-to-lymphocyte ratio (PLR) in patients with PSD.
- To assess if stratifying PLR levels improves PSD prediction.
Main Methods:
- 363 acute ischemic stroke (AIS) patients were analyzed with a 1-month follow-up.
- Patients were stratified into tertiles based on PLR levels.
- PSD was assessed using the 17-item Hamilton Depression Rating Scale.
Main Results:
- 21.2% of patients developed PSD within 1 month.
- Significant differences in PLR tertiles were observed between PSD and non-PSD groups (P < 0.001).
- The highest PLR tertile showed a 5.154-fold increased odds of PSD compared to the lowest tertile, independent of other factors.
Conclusions:
- Increased PLR at admission is a significant independent biomarker for predicting PSD.
- Stratified PLR analysis enhances predictive power for PSD development.
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