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A Heterotopic Mouse Model for Studying Laryngeal Transplantation
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Post-transplantation laryngeal actinomycosis
Hirofumi Sei1, Jumpei Nouta2, Shota Miyaji1
1Department of Otolaryngology, Ehime University, School of Medicine, Toon, Shitsukawa, Ehime 91-0295, Japan.
Auris, Nasus, Larynx
|December 24, 2018
Summary
Laryngeal actinomycosis, a rare infection, can occur after bone marrow transplantation. This case highlights successful treatment with amoxicillin, leading to complete recovery in a young patient.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Hematology
Background:
- Bone marrow transplantation (BMT) can lead to opportunistic infections.
- Laryngeal actinomycosis is a rare fungal infection affecting the larynx.
Observation:
- A 14-year-old girl presented with persistent sore throat post-BMT for acute lymphocytic leukemia.
- Fiberscopy revealed a white, tumor-like mass on the right arytenoid.
- CT imaging showed a localized mass with central low density and granulation tissue.
Findings:
- Biopsy confirmed a soft granulation with sulfur granules, consistent with Actinomyces granuloma.
- Oral amoxicillin treatment was initiated and continued for 70 days.
- Histological confirmation of Actinomyces granuloma led to continued amoxicillin therapy.
Implications:
- This case demonstrates the successful management of laryngeal actinomycosis post-BMT.
- Prompt diagnosis and antibiotic treatment are crucial for favorable outcomes.
- Amoxicillin effectively resolved the infection and prevented recurrence in this immunocompromised patient.
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