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Related Experiment Video

Updated: Jan 31, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Structural and functional brain alterations in obstructive sleep apnea: a multimodal meta-analysis.

Xiao Huang¹, Shi Tang², Xiaojun Lyu¹

¹Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.

|December 24, 2018

Summary

Obstructive sleep apnea (OSA) causes brain changes, including reduced gray matter volume and altered function in key areas like the orbital frontal cortex. These neurostructural and functional abnormalities may explain associated health issues.

Keywords:

Functional magnetic resonance imaging (fMRI)Multimodal Obstructive sleep apnea meta-analysis Voxel-based morphometry (VBM)

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Area of Science:

Neuroimaging
Sleep Medicine
Neurology

Background:

Obstructive sleep apnea (OSA) is a prevalent condition affecting multiple organ systems.
Neuropathophysiological mechanisms underlying OSA-related deficits remain unclear.
Brain alterations are suspected contributors to OSA's systemic effects.

Purpose of the Study:

To investigate neurostructural and functional brain abnormalities in OSA patients.
To compare brain changes in OSA patients versus healthy individuals.
To identify specific and common neural alterations using meta-analysis.

Main Methods:

Conducted separate and multimodal meta-analyses of MRI studies.
Extracted volumetric and functional data from original research.
Utilized anisotropic effect-size version of Signed Differential Mapping (AES-SDM).

Main Results:

Identified shared changes in the orbital frontal cortex (OFC) with decreased gray matter volume (GMV) and function.
Observed decreased GMV in anterior cingulate/paracingulate gyri (ACC/ApCC) and hippocampus/parahippocampal gyrus (Hippo/PHG).
Found DLPFC hypoactivation and insula hyperactivation in OSA patients.

Conclusions:

Demonstrated significant brain structural and functional alterations in OSA patients.
These neural changes may explain associated psychic, memory, cardiovascular, and endocrine issues.
Findings suggest potential for early diagnosis and treatment of OSA-related neurological complications.