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miR-29a attenuates cardiac hypertrophy through inhibition of PPARδ expression

Si Zhang1,2, Zhongnan Yin3, Fei-Fei Dai1

  • 1Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou City, Henan, Peoples's Republic of China.

Journal of Cellular Physiology
|December 24, 2018
PubMed

Insights

MicroRNA-29a (miR-29a) offers a protective role in cardiac hypertrophy by targeting peroxisome proliferator-activated receptor δ (PPARδ) and atrial natriuretic factor (ANF), suggesting its therapeutic potential.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Gene Regulation

Background:

  • Cardiac hypertrophy is a significant risk factor for heart failure, yet its underlying mechanisms are not fully understood.
  • Peroxisome proliferator-activated receptor δ (PPARδ) plays a role in cardiac lipid metabolism.
  • MicroRNAs are emerging as key regulators in cardiovascular disease.

Purpose of the Study:

  • To elucidate the novel molecular cascade involving microRNA-29a (miR-29a), peroxisome proliferator-activated receptor δ (PPARδ), and atrial natriuretic factor (ANF) in cardiac hypertrophy.
  • To investigate the cardioprotective role of miR-29a in isoproterenol hydrochloride-induced cardiac hypertrophy.
  • To assess the therapeutic potential of miR-29a for heart hypertrophy treatment.

Main Methods:

  • Investigated a novel PPARδ-dependent molecular cascade involving miR-29a and ANF.
  • Utilized isoproterenol hydrochloride to induce cardiac hypertrophy in a model system.
  • Assessed the effect of miR-29a on PPARδ and ANF expression and cardiac hypertrophy response.

Main Results:

  • Identified a novel PPARδ-dependent molecular cascade involving miR-29a and ANF that is reactivated in cardiac hypertrophy.
  • Demonstrated that miR-29a exhibits a cardioprotective function by targeting PPARδ and downregulating ANF.
  • Showed that miR-29a reduces isoproterenol hydrochloride-induced cardiac hypertrophy.

Conclusions:

  • miR-29a plays a crucial cardioprotective role in mitigating cardiac hypertrophy.
  • The miR-29a/PPARδ/ANF pathway represents a novel therapeutic target for heart hypertrophy.
  • Further research into miR-29a could lead to new treatments for heart hypertrophy and heart failure.

Keywords:
cardiac hypertrophy; microRNA; nuclear receptor PPARδ; isoproterenol hydrochloride; transcriptional regulation

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