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Related Experiment Videos

Hyperactive boys almost grown up. III. Methylphenidate effects on ultimate height.

R G Klein1, S Mannuzza

  • 1New York State Psychiatric Institute, NY 10032.

Archives of General Psychiatry
|December 1, 1988
PubMed
Summary

Methylphenidate hydrochloride treatment for childhood hyperactivity does not affect final adult height. Children experience a growth rebound after stopping the medication, reaching typical stature.

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Area of Science:

  • Pediatric Endocrinology
  • Neurodevelopmental Disorders
  • Pharmacology

Background:

  • Methylphenidate hydrochloride is a common stimulant medication used to treat hyperactivity in children.
  • Concerns exist regarding the potential impact of long-term stimulant use on growth and final adult height.

Purpose of the Study:

  • To investigate the long-term effect of methylphenidate hydrochloride treatment on the final height of young adults.
  • To determine if childhood stimulant therapy compromises adult stature.

Main Methods:

  • A cohort study comparing the final height of young adults treated with methylphenidate hydrochloride in childhood with a control group.
  • Analysis of height data against national US norms.

Main Results:

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  • No significant difference in final height was observed between the methylphenidate-treated group (n=61) and the control group (n=99).
  • Both groups achieved heights consistent with the national US norm.
  • A compensatory growth spurt, or rebound, was noted after stimulant discontinuation.

Conclusions:

  • Methylphenidate hydrochloride therapy does not appear to compromise final adult height.
  • Adverse effects on growth rate during treatment are likely temporary, with catch-up growth occurring post-treatment.