Takotsubo syndrome: State-of-the-art review by an expert panel - Part 2

Area of Science:

• Cardiology
• Internal Medicine

Background:

• Takotsubo syndrome (TTS) is a complex cardiac condition requiring updated consensus.
• Part 2 of this manuscript focuses on biomarkers, complications, and emerging research areas in TTS.

Purpose of the Study:

• To summarize the current understanding of takotsubo syndrome (TTS).
• To highlight novel aspects including genetics, microRNAs, racial differences, and advanced imaging in TTS.
• To propose clinical decision-making algorithms and future research directions for TTS.

Main Methods:

• Consensus paper development through a multinational effort.
• Review of current literature on takotsubo syndrome (TTS) biomarkers and complications.
• Inclusion of novel sections on genetics, microRNAs, racial differences, cardiac spectroscopy, intracoronary imaging, and mechanical circulatory support.

Main Results:

• Discussion of typical biomarkers such as excess catecholamines and electrocardiographic findings in TTS.
• Elaboration on numerous complications associated with takotsubo syndrome (TTS).
• Presentation of new structured algorithms for clinical decision-making in TTS.

Conclusions:

• The consensus paper provides a comprehensive overview of the current state of takotsubo syndrome (TTS).
• Emphasis on emerging areas like genetics, microRNAs, and advanced imaging offers new insights.
• Proposed algorithms and research directions aim to improve clinical management and address evidence gaps in TTS.