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C-reactive protein level in late-onset depression: A case-control study.

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Summary

Late-onset depression (LOD) shows higher C-reactive protein (CRP) levels compared to controls. Increased CRP is linked to greater depression severity in LOD patients, suggesting inflammation plays a role.

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Area of Science:

  • Psychiatry
  • Immunology
  • Cardiovascular Disease

Background:

  • Late-onset depression (LOD) is less responsive to standard treatments.
  • LOD is linked to vascular risk factors, atherosclerosis, and immune dysregulation.
  • Inflammatory activity is hypothesized to be associated with LOD.

Purpose of the Study:

  • To compare C-reactive protein (CRP) levels in LOD patients versus age-matched controls.
  • To investigate the association between CRP levels and the severity of depressive episodes in LOD.

Main Methods:

  • A case-control study was conducted in a tertiary care psychiatry department.
  • Participants included patients with LOD (>55 years) and age-matched controls.
  • Clinical assessments, vascular risk factor evaluation, serum CRP measurement, and depression severity (HDRS) were performed.

Main Results:

  • Patients with LOD had 40% higher CRP levels than controls.
  • A strong positive correlation (r=0.935, P<0.001) was found between CRP levels and depression severity (HDRS).

Conclusions:

  • LOD is associated with elevated CRP levels compared to non-depressed individuals.
  • Higher CRP levels correlate with increased depression severity in late-onset depression.