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Enhancing Antitumor Efficacy by Simultaneous ATP-Responsive Chemodrug Release and Cancer Cell Sensitization Based on

Xiao-Rong Song1,2, Shi-Hua Li2, Hanhan Guo1

  • 1CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 25, 2018
PubMed

Insights

Engineered smart nanoagents deliver drugs effectively in cancer cells by responding to adenosine triphosphate (ATP). This novel approach enhances chemotherapy by depleting ATP and increasing cancer cell sensitivity, improving treatment outcomes.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapeutics

Background:

  • Smart nanoagents for drug delivery systems (DDSs) show promise in cancer treatment.
  • Current nanoagents face challenges in synthesis, drug release, and cancer cell chemosensitivity.

Purpose of the Study:

  • To engineer an adenosine triphosphate (ATP)-activatable nanoagent for improved cancer chemotherapy.
  • To address limitations of current nanoagents, including complex synthesis and insufficient drug efficacy.

Main Methods:

  • Developed a one-step self-assembly of quantum dots-phenolic nanoclusters into a smart nanoagent.
  • Investigated ATP-activated disassembly and controlled drug delivery mechanisms.
  • Conducted in vitro and in vivo studies for efficacy, imaging, and clearance assessment.

Main Results:

  • The nanoagent demonstrated high drug loading and low cytotoxicity to normal cells.
  • Achieved ATP-activated drug release and induced cancer cell ATP depletion.
  • Showcased enhanced tumor accumulation, intracellular ATP imaging, and body clearance.

Conclusions:

  • The multifunctional nanoagent offers enhanced antitumor efficacy through ATP-responsive drug release and cancer cell sensitization.
  • Provides novel insights for designing advanced nanoagents for cancer therapeutics.
  • Highlights the potential of ATP-activatable systems in improving cancer treatment strategies.
Keywords:
antitumorcell sensitizationchemodrugsnanoagentsquantum dots

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