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A high efficiency membrane separator for donor plasmapheresis.

B J Bellhouse1, R W Lewis

  • 1University of Oxford, Department of Engineering Science, United Kingdom.

ASAIO Transactions
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

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New membrane separators address the human plasma shortage using vortex mixing. This innovative design enhances plasma filtration rates, offering a promising solution for therapeutic plasma needs.

Area of Science:

  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Donor plasmapheresis is essential for meeting therapeutic human plasma demands.
  • Conventional membrane plasma separators exhibit poor performance at low blood flow rates and are prone to fouling.

Purpose of the Study:

  • To develop and evaluate a novel membrane blood plasma separator that overcomes the limitations of conventional designs.
  • To improve plasma filtration efficiency and reduce membrane fouling.

Main Methods:

  • Development of a membrane separator with a single blood channel featuring dimpled membranes to induce vortex mixing.
  • Utilized oscillating diaphragms at 3-6 Hz with a 2.8 ml stroke volume to enhance blood flow dynamics.
  • Tested in clinical trials with human blood and experiments with bovine blood.

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Main Results:

  • Achieved a mean plasma filtration rate of 18 ml/min at 48 ml/min blood inlet flow in clinical trials.
  • Demonstrated a mean plasma filtration rate of 35 ml/min at 90 ml/min blood inlet flow using bovine blood.
  • Exhibited stable performance over 80 minutes with minimal reduction in efficiency.
  • Reported a filtration velocity of 1.75 L/min/m², five times higher than conventional hollow fiber or flat plate designs.

Conclusions:

  • The novel vortex-mixing membrane separator effectively addresses the limitations of conventional designs.
  • This technology offers significantly improved plasma filtration rates and sustained performance.
  • Represents a promising advancement for therapeutic plasma separation and addressing plasma shortages.