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The Role of Probiotics in the Prevention of Necrotizing Enterocolitis

Ivana Trivić1, Ana Savić Mlakar2, Iva Hojsak1,3,4

  • 1Children's Hospital Zagreb, Zagreb, Croatia.

Current Pediatric Reviews
|December 25, 2018
PubMed

Insights

Necrotizing enterocolitis (NEC), a severe infant condition, may be prevented by probiotics. This review examines evidence on probiotics and specific strains for preventing NEC in preterm infants.

Area of Science:

  • Neonatal medicine
  • Gastroenterology
  • Microbiology

Background:

  • Necrotizing enterocolitis (NEC) is a critical gastrointestinal disease impacting preterm infants.
  • Identifying preventive strategies is crucial due to NEC's high incidence in this specific population.
  • Nutritional interventions, particularly probiotics, are being explored for NEC prevention.

Purpose of the Study:

  • To review the current evidence on the efficacy of probiotics in preventing NEC.
  • To evaluate specific probiotic strains and combinations for NEC prevention in preterm infants.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of studies investigating probiotic use in preterm infants.
  • Assessment of outcomes related to NEC incidence.

Main Results:

  • Evidence suggests probiotics can reduce NEC incidence.
  • Specific strains and combinations show varying degrees of effectiveness.
  • Further research is needed to optimize probiotic use.

Conclusions:

  • Probiotics represent a promising strategy for NEC prevention in preterm infants.
  • Strain-specific efficacy requires further investigation for targeted therapeutic approaches.
  • Optimizing probiotic administration could significantly decrease NEC morbidity and mortality.

Keywords:
NECPremature infantmicrobiotaneonatepatientsprobioticssepsis.

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