Related Experiment Video
Updated: Jan 31, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
MATHEMATICAL ANALYSIS OF FUNCTIONAL PROPERTIES OF MICE BONE MARROW IN THE INITIAL PHASE OF ACUTE FRACTIONATED
R V Boiko1, D I Bilko1, I Z Russu1
1National University of Kyiv-Mohyla Academy, G. Skovorody Str. 2, Kyiv 04070.
Objective:
to determine the quantitative characteristics of population functioning of mice bone marrow colony-forming units during seven days of acute fractionated irradiation.
Materials And Methods:
Assigned task is solved by means of described in works R. V. Boiko et al. (2015, 2016) math-ematical model of alterations in the number of bone marrow colony-forming units using the experimental results ofwork W.Chu-Tse, L. G.Lajtha (1975). Mathematical model is developed basing on the new hematopoiesis scheme,which was introduced by I. Chertkov(1984, 1991).
Results:
By applying original mathematical model of hematopoiesis scheme using results concerning the change innumber of bone marrow colony-forming units of mice femur we determined quantitative characteristics of theirfunctioning during seven days of fractionated irradiation under daily acute γ-radiation in the dose of 0.7 Gy.
Conclusions:
Mathematical model is introduced, which describes changes in the relative number of colony-formingunits in mice bone marrow in the process of their acute fractionated irradiation.
Related Concept Videos
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Properties of Continuous Functions
Initiation of Translation
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
Initiation of Translation
Integration of Rational Functions Using Partial Fractions
Mathematical Induction

