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Evaluation of the Storage Stability of Extracellular Vesicles
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Extracellular Vesicles: New Players in Lymphomas.

Victor Navarro-Tableros1, Yonathan Gomez2, Giovanni Camussi3

  • 12i3T Società per la gestione dell'incubatore di imprese e per il trasferimento tecnologico Scarl, University of Turin, Turin 10126, Italy. victor.navarro@2i3t.it.

International Journal of Molecular Sciences
|December 26, 2018
PubMed
Summary

Lymphoma cell-derived extracellular vesicles (LCEVs) in blood show potential as biomarkers for diagnosis, disease progression, and treatment response. Research is exploring LCEVs for targeted therapies and non-invasive treatments.

Keywords:
extracellular vesiclesimmunomodulationinnovative therapieslymphoma

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Lymphomas are diverse hematological cancers with varying clinical and molecular characteristics.
  • Lymphoma cell-derived extracellular vesicles (LCEVs) are detectable in patient blood and their levels/phenotypes change with disease progression and treatment.
  • LCEVs play a role in tumor immune evasion and can protect lymphoma cells from therapies like anti-CD20.

Purpose of the Study:

  • To review the role of LCEVs in lymphoma diagnosis, immune tolerance, and drug resistance.
  • To discuss LCEVs as potential biomarkers for disease progression and treatment response.
  • To explore therapeutic strategies targeting LCEVs.

Main Methods:

  • Literature review and analysis of existing research on LCEVs in lymphoma.
  • Discussion of LCEV detection through liquid biopsies, serum EV quantification, and cargo analysis.
  • Exploration of therapeutic approaches including targeted vaccines, antibodies, and LCEV removal.

Main Results:

  • LCEVs exhibit characteristics reflecting their cell of origin, making them suitable targets for diagnostics and therapeutics.
  • Circulating LCEVs can confer resistance to certain cancer treatments.
  • LCEVs hold promise as predictive biomarkers for disease progression and treatment efficacy.

Conclusions:

  • LCEVs represent promising novel biomarkers for lymphoma diagnosis and monitoring.
  • Targeting LCEVs offers potential for developing new therapeutic strategies, including vaccines and antibodies.
  • Investigating LCEVs is crucial for advancing lymphoma management and patient outcomes.