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Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

440
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Drug-Receptor Interactions01:29

Drug-Receptor Interactions

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Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
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Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
247
Factors Affecting Protein-Drug Binding: Drug Interactions01:23

Factors Affecting Protein-Drug Binding: Drug Interactions

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Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
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Drug-Receptor Interaction: Antagonist01:28

Drug-Receptor Interaction: Antagonist

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An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
Antagonists can be classified as competitive or noncompetitive based on their...
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Drug-Receptor Interaction: Agonist01:25

Drug-Receptor Interaction: Agonist

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Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
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Related Experiment Video

Updated: Jan 31, 2026

Employing Aeroponic Systems for the Clonal Propagation of Cannabis
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Employing Aeroponic Systems for the Clonal Propagation of Cannabis

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Medicinal Cannabis-Potential Drug Interactions.

Muhammad A Alsherbiny1,2, Chun Guang Li3

  • 1NICM Health Research Institute, Western Sydney University, Westmead, NSW 2145, Australia. Muhammad.alsherbiny@pharma.cu.edu.eg.

Medicines (Basel, Switzerland)
|December 26, 2018
PubMed
Summary

Medicinal cannabis (cannabinoids) may interact with other drugs through altered metabolism and transport. Healthcare providers should monitor patients, especially the elderly or those with chronic conditions, for potential adverse effects.

Keywords:
BCRPCBDCannabisMRPsTHCUDP-glucuronosyltransferasescannabinoidscytochrome P450drug–drug interactionsglycoprotein ppharmacokinetic

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Area of Science:

  • Pharmacology
  • Oncology
  • Neuroscience

Background:

  • The endocannabinoid system (ECS) is a therapeutic target for cancer and neurodegenerative diseases.
  • Cannabinoids influence appetite, energy balance, pain, and chemotherapy-induced nausea and vomiting (CINV).

Purpose of the Study:

  • To review potential drug-drug interactions of medicinal cannabis.
  • To inform healthcare practitioners about cannabinoid interactions with prescription medications.

Main Methods:

  • Review of existing literature on cannabinoid drug interactions.
  • Analysis of pharmacokinetic and pharmacodynamic interaction mechanisms.

Main Results:

  • Cannabinoids can interact with other drugs via membrane transporters (e.g., P-glycoprotein) and metabolizing enzymes (e.g., Cytochrome P450).
  • Bidirectional effects are possible with concomitant administration of cannabinoids and other medications.

Conclusions:

  • Caution is advised when prescribing medicinal cannabis, particularly for vulnerable populations.
  • Close monitoring of patients is essential to ensure safety and manage potential drug interactions.