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An update on polyphenol disposition via coupled metabolic pathways.

Liping Wang1, Rongjin Sun1, Qisong Zhang1

  • 1a Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine , Guangzhou University of Chinese Medicine , Guangzhou, Guangdong , China.

Expert Opinion on Drug Metabolism & Toxicology
|December 26, 2018
PubMed
Summary

Polyphenols have low bioavailability due to complex metabolic pathways. Understanding the interaction between drug metabolic enzymes (DMEs), efflux transporters (ETs), and gut bacteria is key to enhancing polyphenol absorption.

Keywords:
Drug metabolic enzymesefflux transportersintestinal microbiotanuclear receptorspolyphenols

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