Intravenous versus Subcutaneous Midazolam Using Jet-injector in Pediatric Sedation; a Randomized Clinical Trial

Area of Science:

• Pediatric Emergency Medicine
• Pharmacology
• Clinical Trials

Background:

• Effective pediatric sedation is crucial for medical interventions.
• Midazolam is commonly used for sedation induction in children.
• Comparing subcutaneous (SC) and intravenous (IV) administration routes is essential for optimizing pediatric care.

Purpose of the Study:

• To compare the sedative effects of SC and IV midazolam in children aged 1-6 years.
• To evaluate success rate, sedation depth, and satisfaction levels of parents and physicians.
• To determine the optimal route for midazolam administration in pediatric sedation.

Main Methods:

• A randomized clinical trial involving 60 children aged 1-6 years.
• Participants were randomly assigned to receive either SC or IV midazolam via jet injector.
• Key outcomes included sedation depth, child control, physician and parent satisfaction, sedation success, and recovery time.

Main Results:

• No significant differences were observed in sedation depth, child control, physician satisfaction, or successful sedation between SC and IV midazolam groups.
• The IV midazolam group demonstrated a significantly shorter recovery time (approximately 10 minutes).
• Parents reported significantly higher satisfaction with the SC midazolam administration.

Conclusions:

• Both SC and IV midazolam are effective for pediatric sedation induction, with comparable success rates and physician satisfaction.
• SC midazolam administration leads to greater parent satisfaction.
• IV midazolam offers a faster recovery period for pediatric patients.