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Updated: Jan 31, 2026
An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
Published on: October 25, 2019
[Effect of cryopreserved cord blood nucleated cells on course of pathological processes in progressive aging of brain
V S Aidarova1, V G Babijchuk1, I I Lomakin1
1Institute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of Ukraine, 23, Pereyaslavska str., Kharkov, Ukraine, 61016;
Abstract:
The data on morphometric indices of the vascular bed and brain substance of spontaneously hypertensive SHR rats, which can be considered as an evidence of the developing pathological brain aging processes in these animals, are presented in the work. Chronic alcohol intoxication aggravates the neurodegeneration, significantly reducing the indices of the neuroglial index, the number of functioning vessels and activating the LPO processes. Single intraperitoneal administration of cryopreserved human cord blood nucleated cells in a dose of (1-5)‧107/kg promoted the regeneration of neurocells, stimulation of angiogenesis and an increased level and quality of neurotissue metabolism, reducing the signs of dystrophic, destructive and pathologically altered compensatory adaptive processes in the rat's brain as a result of the restoration of its microhemocirculation and cytoarchitecture.
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