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Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts
Atsushi Sanagawa1, Hideo Nagashima1
1Institute for Materials Chemistry and Engineering , Kyushu University , Kasuga , Fukuoka 816-8580 , Japan.
Abstract:
Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPiv)2 (Piv = CO tBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.
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