Two new compounds from Streptomyces sp. HS-NF-813

Area of Science:

• Natural Products Chemistry
• Microbial Secondary Metabolites
• Pharmacology

Background:

• Cytotoxic substances are crucial in cancer therapy research.
• The strain *Streptomyces* sp. HS-NF-813 is a source of bioactive compounds.

Purpose of the Study:

• To isolate and characterize new cytotoxic derivatives of BE-52211.
• To evaluate the cytotoxic potential of these novel compounds against human tumor cell lines.

Main Methods:

• Isolation from fermentation broth of *Streptomyces* sp. HS-NF-813.
• Structure elucidation using 1D/2D NMR, ESI-MS, and literature data.
• Absolute stereochemistry determination via Mosher ester derivatives.

Main Results:

• Two new derivatives, BE-52211D (1) and BE-52211E (2), were successfully isolated.
• The chemical structures of compounds 1 and 2 were fully determined.
• Compounds 1 and 2 exhibited moderate cytotoxic activity against three human tumor cell lines.

Conclusions:

• The discovery of BE-52211D and BE-52211E expands the library of cytotoxic agents.
• These compounds warrant further investigation for their anticancer properties.