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A Patient-Centered Approach to Comparative Effectiveness Research Focused on Older Adults: Lessons From the
Noah R Mason1, Harold C Sox1, Evelyn P Whitlock1
1Patient-Centered Outcomes Research Institute, Washington, District of Columbia.
Journal of the American Geriatrics Society
|December 27, 2018
Summary
The Patient-Centered Outcomes Research Institute (PCORI) funds research for older adults. Key factors for comparative effectiveness research (CER) in this population include patient preferences and competing risks.
Area of Science:
- Gerontology
- Health Services Research
- Comparative Effectiveness Research
Background:
- The Patient-Centered Outcomes Research Institute (PCORI) has invested significantly in research for older adults since 2012.
- Comparative Effectiveness Research (CER) is crucial for informing healthcare decisions in aging populations.
Purpose of the Study:
- To share insights on conducting CER for older adults.
- To highlight critical factors for evaluating interventions in this demographic.
Main Methods:
- Review of PCORI's research portfolio focused on older adults.
- Identification of key considerations for CER in geriatric populations.
Main Results:
- Essential factors for CER in older adults include absolute risk difference, competing risks, life expectancy, and the distinction between chronological and physiological age.
- Patient preferences and other variable treatment effect drivers are critical.
- Engaging older adults and caregivers as research partners is vital for identifying relevant outcomes and research conduct insights.
Conclusions:
- Effective CER for older adults requires careful consideration of unique geriatric factors.
- Patient and caregiver engagement is paramount for successful research and informed decision-making.
Keywords:
comparative effectiveness researchgeriatricsolder adultspatient-centered outcomes researchtreatment response heterogeneityMore Related Videos
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