Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Correlation of Experimental Data01:23

Correlation of Experimental Data

486
Dimensional analysis simplifies complex physical problems and guides experimental investigations, but it does not provide complete solutions. It identifies the dimensionless groups that influence a phenomenon, but experimental data is needed to establish the specific relationships and validate theoretical predictions.
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
486
Correlations02:20

Correlations

35.9K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.9K
Correlation and Causation01:27

Correlation and Causation

42.6K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.6K
Correlation01:09

Correlation

15.1K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.1K
Correlation and Regression00:53

Correlation and Regression

3.4K
In statistics, correlation describes the degree of association between two variables. In the subfield of linear regression, correlation is mathematically expressed by the correlation coefficient, which describes the strength and direction of the relationship between two variables. The coefficient is symbolically represented by 'r' and ranges from -1 to +1. A positive value indicates a positive correlation where the two variables move in the same direction. A negative value suggests a...
3.4K
Coefficient of Correlation01:12

Coefficient of Correlation

8.7K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable x and the dependent variable y.
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PRELIMINARY ASSESSMENT OF SERUM AMYLOID A AND PROTEIN ELECTROPHORESIS IN THE TIGER (<i>PANTHERA TIGRIS</i>) AND LION (<i>PANTHERA LEO</i>).

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2026
Same author

PRELIMINARY ASSESSMENT OF SERUM CAPILLARY ZONE ELECTROPHORESIS IN SIX NONDOMESTIC BOVID SPECIES.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2026
Same author

Optimized tRNA structure-seq reveals robust tRNA secondary structures in <i>S. cerevisiae</i> under mild stress conditions.

RNA (New York, N.Y.)·2026
Same author

Temporal versus superior clear corneal incision for eyes with oblique astigmatism: a randomized comparative study.

Japanese journal of ophthalmology·2026
Same author

Normative assessment of corneal thickness and iridocorneal angle parameters in guinea pigs (Cavia porcellus) using spectral-domain optical coherence tomography.

Veterinary research communications·2026
Same author

Correction: Six-Year Outcomes in Subjects with Polypoidal Choroidal Vasculopathy in the PLANET Study.

Ophthalmology and therapy·2026
Same journal

Persistent placoid maculopathy: long term outcomes and prognostic factors.

Retina (Philadelphia, Pa.)·2026
Same journal

ANTI-VEGF THERAPY SWITCHING RETINAL DISEASES: Characterizing Clinical Manifestations and Common Involved Genes: ERRATUM.

Retina (Philadelphia, Pa.)·2026
Same journal

THE EFFICACY AND SAFETY OF SUBRETINAL BALANCED SALT SOLUTION INJECTION IN DIABETIC MACULAR EDEMA WITH HARD EXUDATES: ERRATUM.

Retina (Philadelphia, Pa.)·2026
Same journal

EVALUATING CLINICAL OUTCOMES OF AMNIOTIC MEMBRANE COVERAGE COMBINED WITH EARLY VITRECTOMY IN THE MANAGEMENT OF PERFORATING GLOBE INJURIES.

Retina (Philadelphia, Pa.)·2026
Same journal

Mid-Phase Hyperfluorescent Plaques as a biomarker of disease activity in Central Serous Chorioretinopathy: Clinical Course and Treatment Response - MICRoN report number Ten.

Retina (Philadelphia, Pa.)·2026
Same journal

Severe retinal non-perfusion is associated with fewer retinal lesions on ultra-wide field fundus photography in proliferative diabetic retinopathy.

Retina (Philadelphia, Pa.)·2026
See all related articles

Related Experiment Video

Updated: Jan 31, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
07:20

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

10.5K

CORRELATIONS BETWEEN EXPERIMENTAL MYOPIA MODELS AND HUMAN PATHOLOGIC MYOPIA.

Kritchai Vutipongsatorn1, Natsuko Nagaoka2, Tae Yokoi2

  • 1Department of Medicine, Imperial College London, London, United Kingdom.

Retina (Philadelphia, Pa.)
|December 27, 2018
PubMed
Summary
This summary is machine-generated.

Animal models like LRP2 knockout mice and specific chicks show key features of pathologic myopia. These models aid in understanding the development of myopic maculopathy in humans.

More Related Videos

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.3K
Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
05:26

Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

Published on: April 12, 2024

2.5K

Related Experiment Videos

Last Updated: Jan 31, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
07:20

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

10.5K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.3K
Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
05:26

Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

Published on: April 12, 2024

2.5K

Area of Science:

  • Ophthalmology
  • Genetics
  • Animal Models

Background:

  • Pathologic myopia is a severe form of myopia characterized by progressive axial elongation and posterior pole abnormalities.
  • Understanding the pathogenesis of pathologic myopia is crucial for developing effective treatments.
  • Animal models offer valuable tools for studying complex ocular diseases like pathologic myopia.

Purpose of the Study:

  • To analyze hallmark features of pathologic myopia in animal models.
  • To compare these features with those observed in human patients with pathologic myopia.
  • To identify suitable animal models for future research into myopic maculopathy.

Main Methods:

  • A comprehensive literature review was conducted to identify relevant animal models.
  • Key features of pathologic myopia (posterior staphyloma, myopic maculopathy, lacquer cracks, choroidal neovascularization) were investigated.
  • Imaging modalities including OCT, confocal scanning laser ophthalmoscopy, and fluorescein angiography were used for comparison with human data.

Main Results:

  • LRP2 knockout mice displayed posterior staphylomas and chorioretinal atrophy.
  • Retinopathy globe enlarged (RGE) chicks and lid-sutured chicks developed lacquer cracks and chorioretinal atrophy.
  • Lacquer cracks in RGE chicks progressed to patchy chorioretinal atrophy, mirroring human disease progression.

Conclusions:

  • LRP2 knockout mice, RGE chicks, and lid-sutured chicks exhibit features consistent with human myopic maculopathy.
  • These animal models are valuable for elucidating the pathogenesis of myopic maculopathy.
  • Further research using these models can advance our understanding and treatment strategies for pathologic myopia.