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Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Antibiotic resistance pattern shown by various pathogens, causing infections in neonates.

Zaib Ali Shaheryar1, Zakaur Rehman1, Muhammad Zaman1

  • 1Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.

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Bacterial resistance in newborns is rapidly increasing, with common antibiotics becoming ineffective against emerging resistant strains. This trend significantly limits treatment options for neonatal infections, demanding urgent attention.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Neonatal Care

Background:

  • Neonatal infections pose a significant threat to infant health.
  • Empirical antibiotic therapy is crucial for treating suspected neonatal bacterial infections.
  • Rising antibiotic resistance complicates effective treatment strategies.

Purpose of the Study:

  • To investigate current trends in bacterial resistance among neonatal pathogens.
  • To assess the efficacy of commonly used empirical antibiotics against these pathogens.
  • To identify specific antibiotic resistance patterns in neonatal bacterial isolates.

Main Methods:

  • Isolation and identification of bacterial pathogens from neonatal samples.
  • Performance of antibiotic sensitivity testing on isolated pathogens.
  • Analysis of resistance patterns for gram-positive and gram-negative bacteria.

Main Results:

  • Significant antibiotic resistance was observed in both gram-positive and gram-negative neonatal bacterial isolates.
  • Commonly relied-upon antibiotics, including Amikacin sulphate and Piperacillin/Tazobactam, showed reduced efficacy.
  • Emerging resistance was noted against a broad spectrum of antibiotics like Linezolid, Vancomycin, and Ciprofloxacin.

Conclusions:

  • Antibiotic resistance in neonatal pathogens is a rapidly evolving and concerning issue.
  • The effectiveness of many empirical antibiotics is diminishing, narrowing therapeutic options.
  • Urgent strategies are needed to address the growing challenge of antibiotic resistance in neonatal infections.