Related Experiment Video
Updated: Jan 31, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?
Douglas B Johnson1, Justin M Balko2
1Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee. douglas.b.johnson@vumc.org.
Abstract:
Immune checkpoint inhibitors induce durable responses in some patients with advanced cancer but may simultaneously trigger autoinflammatory immune-related adverse events (irAE). The pathogenesis of irAEs may relate to genetic predisposition, environmental insults, or tumor-host interactions. Elevated expression of certain cytokines may signal subclinical inflammation that evolves into severe irAEs with treatment.See related article by Lim et al., p. 1557.
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