Related Experiment Video

Updated: Jan 26, 2026

Optimization of the Cuff Technique for Murine Heart Transplantation
14:01

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

10.1K

Survival of Heart Transplant Candidates in Japan

Shinichi Nunoda1, Taro Sasaoka2, Yasushi Sakata3

  • 1Department of Therapeutic Strategy for Severe Heart Failure, Graduate School of Medicine, Tokyo Women's Medical University.

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 28, 2018
PubMed

Insights

Japan faces a shortage of heart transplant (HTX) organs. This study found pediatric patients did not have better survival than adults, suggesting prioritization for pediatric heart transplantation is needed.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Pediatric Critical Care

Background:

  • Organ scarcity for heart transplantation (HTX) is a critical issue in Japan.
  • A significant number of pediatric and adult patients are on the HTX waiting list.

Purpose of the Study:

  • To compare survival outcomes between pediatric and adult patients awaiting heart transplantation in Japan.
  • To evaluate the current HTX candidacy criteria and inform organ allocation policies.

Main Methods:

  • Retrospective analysis of 68 pediatric and 366 adult patients (<60 years) applying for HTX candidacy since July 2010.
  • Comparison of freedom from death or HTX between different patient groups (pediatric Status 1 vs. 2; adult Status 1 vs. 2).

Main Results:

  • No significant difference in survival was observed between pediatric Status 1 and Status 2 patients.
  • Adult Status 1 patients experienced higher rates of death or HTX compared to adult Status 2 patients.
  • Pediatric patients (both Status 1 and 2) did not demonstrate superior survival rates compared to adult patients (Status 1 or 2).

Conclusions:

  • Current data do not support better survival for pediatric patients compared to adults awaiting heart transplantation.
  • Re-evaluation of prioritization criteria for pediatric heart transplantation in Japan may be warranted.
  • Consideration should be given to prioritizing pediatric patients for limited donor organs based on these findings.
Abstract

Keywords:
Heart transplantationJapanSurvivalWaiting list status

More Related Videos

Murine Heterotopic Heart Transplant Technique10:27

Murine Heterotopic Heart Transplant Technique

Published on: July 8, 2014

17.6K
A Modified Method for Heterotopic Mouse Heart Transplantion11:29

A Modified Method for Heterotopic Mouse Heart Transplantion

Published on: June 23, 2014

13.1K

Related Concept Videos

Survival Tree01:19

Survival Tree

Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a...
411
Survival Curves01:18

Survival Curves

Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
688
Introduction To Survival Analysis01:18

Introduction To Survival Analysis

Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
770
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
582
Truncation in Survival Analysis01:09

Truncation in Survival Analysis

Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
608
Censoring Survival Data01:09

Censoring Survival Data

Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
536