Related Experiment Video
Updated: Jan 31, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Status epilepticus alert reduces time to administration of second-line antiseizure medications
Mauricio F Villamar1, Aaron M Cook1, Chenlu Ke1
1Departments of Neurology (MFV, JLC, KSD, RW-M, LBG, MB-O) and Statistics (CK, YX), University of Kentucky, Lexington; Department of Neurology (MFV), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and UK HealthCare Pharmacy Services (AMC), Lexington, KY.
Background:
Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. Delays in SE treatment are common in clinical practice and can be associated with poorer outcomes. Our goal was to determine whether the implementation of an SE alert protocol improves time to administration of a second-line antiseizure medication (ASM) in hospitalized adults.
Methods:
We developed and implemented an inpatient SE alert system. A quasiexperimental cohort study was performed. We analyzed all patients aged 18-85 years who were managed at the University of Kentucky Medical Center using the SE alert protocol between March 2015 and June 2017 (n = 19). Controls were the first 20 consecutive patients treated for SE over the same time period, but who were managed with usual care (i.e., without SE alert protocol).
Results:
Time to administration of a second-line ASM was shorter with the use of the SE alert system (22.21 ± 3.44 minutes) compared to usual care (58.30 ± 6.72 minutes; p < 0.0001).
Conclusion:
Implementation of an SE alert system led to a marked improvement in time to administration of a second-line ASM.
Classification Of Evidence:
This study provides Class III evidence that for adult inpatients treated for SE, implementation of an SE alert protocol reduces time to administration of second-line ASM.
More Related Videos
08:28Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
Related Concept Videos
Inhaled Medications
Marcia's Theory of Identity Status
Reducing Line Loss
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Endocarditis III: Medical Management
Myocarditis III: Medical Management