[Management strategy of intra-abdominal infection caused by multidrug-resistant bacteria]

Area of Science:

• Medical Microbiology
• Infectious Diseases
• Surgical Infections

Background:

• Intra-abdominal infections (IAIs) are common, often stemming from trauma, surgery, or gastrointestinal issues.
• Increasing antimicrobial resistance poses a significant clinical challenge, especially for hospital-acquired IAIs.
• Multidrug-resistant (MDR) bacteria, predominantly Gram-negative, are a major concern in IAIs.

Purpose of the Study:

• To review common types, early diagnosis, and risk factors of MDR bacteria in IAIs.
• To outline current treatment strategies for IAIs caused by MDR bacteria.
• To emphasize comprehensive management including source control, antimicrobial therapy, and supportive care.

Main Methods:

• Literature review summarizing common MDR bacterial types, diagnostic approaches, and risk factors.
• Description of multi-faceted treatment strategies for MDR IAIs.
• Discussion of supportive care measures such as resuscitation, organ support, and nutritional therapy.

Main Results:

• Identified common MDR bacterial pathogens and their associated risk factors in IAIs.
• Detailed a four-pronged treatment approach: anti-infective medication, infection source control, resuscitation/organ support, and nutritional support.
• Highlighted the importance of gastrointestinal function recovery and preventing secondary infections.

Conclusions:

• Managing MDR IAIs necessitates a thorough understanding of risk factors and pathogen characteristics.
• Integrated treatment combining rational antimicrobial use, effective source control, and robust organ support is crucial.
• Nutritional support plays a vital role in promoting recovery and preventing complications in MDR IAIs.