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HIV-associated psoriasis: Epidemiology, pathogenesis, and management
Manuela Ceccarelli1, Emmanuele Venanzi Rullo1,2, Mario Vaccaro1
1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Dermatologic Therapy
|December 28, 2018
Summary
People living with HIV experience severe psoriasis. While antiretroviral therapy improves outcomes, immunosuppressants are often needed but require further safety and efficacy studies in this population.
Area of Science:
- Dermatology
- Immunology
- Infectious Diseases
Background:
- People living with HIV (PLWH) have a higher incidence of skin disorders, including severe and prolonged psoriasis.
- HIV infection's impact on CD4+ T-cell count presents a paradox, as psoriasis exacerbations are more frequent in PLWH.
Purpose of the Study:
- To review the challenges and therapeutic options for psoriasis in PLWH.
- To highlight the need for further research on immunosuppressant safety and efficacy in PLWH with psoriasis.
Main Methods:
- Review of existing literature on HIV and psoriasis.
- Analysis of therapeutic interventions, including combined antiretroviral therapy and immunosuppressants.
Main Results:
- Combined antiretroviral therapy has improved HIV and psoriasis outcomes in PLWH.
- Severe psoriasis in PLWH often necessitates immunosuppressant use, but data on their safety and efficacy is limited.
Conclusions:
- While antiretroviral therapy has advanced care, managing severe psoriasis in PLWH remains challenging.
- More extensive studies are crucial to establish the safety and effectiveness of immunosuppressive drugs for psoriasis and other autoimmune conditions in PLWH.
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