Related Experiment Video

Updated: Jan 31, 2026

Actin Co-Sedimentation Assay; for the Analysis of Protein Binding to F-Actin
07:53

Actin Co-Sedimentation Assay; for the Analysis of Protein Binding to F-Actin

Published on: March 28, 2008

20.0K

Cytoskeleton actin-binding proteins in clinical behavior of pituitary tumors

G Mantovani1, D Treppiedi1, E Giardino1

  • 1Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Endocrine-Related Cancer
|December 28, 2018
PubMed

Insights

Pituitary tumor cells

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Pituitary tumors often exhibit local invasiveness and resistance to current treatments.
  • The molecular mechanisms underlying pituitary tumor behavior are not fully understood.
  • Cytoskeleton protein activity is increasingly recognized as a key factor in tumor invasiveness and drug resistance.

Purpose of the Study:

  • To review evidence on the role of filamin A (FLNA) in pituitary tumor drug responsiveness.
  • To explore the involvement of cofilin in regulating pituitary tumor cell invasiveness.
  • To discuss the molecular regulation of FLNA in pituitary tumors.

Main Methods:

  • Literature review of experimental evidence.
  • Analysis of the role of actin-binding proteins in pituitary tumor biology.
  • Discussion of molecular mechanisms regulating protein expression and function.

Main Results:

  • Filamin A (FLNA) influences somatostatin and dopamine receptor expression and signaling, affecting drug response.
  • Cofilin activation status, modulated by FLNA, impacts pituitary tumor cell invasiveness.
  • Dopaminergic and somatostatinergic drugs may modulate cofilin activity via FLNA.

Conclusions:

  • FLNA is a critical regulator of both drug responsiveness and invasiveness in pituitary tumors.
  • Targeting cytoskeleton proteins like FLNA and cofilin may offer new therapeutic strategies.
  • Further research into FLNA regulation is needed for improved pituitary tumor treatment.
Keywords:
cofilindopamine receptor type 2filamin Apituitary tumorssomatostatin receptor 2

More Related Videos

Measuring Protein Binding to F-actin by Co-sedimentation06:17

Measuring Protein Binding to F-actin by Co-sedimentation

Published on: May 18, 2017

17.2K
Study of the Actin Cytoskeleton in Live Endothelial Cells Expressing GFP-Actin08:37

Study of the Actin Cytoskeleton in Live Endothelial Cells Expressing GFP-Actin

Published on: November 18, 2011

27.7K

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.1K
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
10.4K
Polarity of the Cytoskeleton01:18

Polarity of the Cytoskeleton

The intrinsic polarity of cells can be primarily attributed to two factors- i) the asymmetric accumulation of mobile components such are regulatory molecules and subcellular components across the cell and ii) the orientation of polar cytoskeletal filaments that make up the cytoskeletal networks, specifically microfilaments, and microtubules arranged along the axis of polarity. Interactions between the cytoskeletal filaments are crucial for the establishment and maintenance of the polar nature...
25.3K
The Pituitary Gland01:17

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
10.8K
Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

Factors Affecting Protein-Drug Binding: Protein-Related Factors

Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
558
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.0K