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The association between preeclampsia and autism spectrum disorders among children: a meta-analysis
Ensiyeh Jenabi1, Manoochehr Karami2, Salman Khazaei2
1Pediatric Developmental Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Insights
Preeclampsia is linked to a higher risk of autism spectrum disorders (ASDs) in children. This meta-analysis confirms a significant association between maternal preeclampsia and ASD development.
Area of Science:
- Perinatal epidemiology
- Neurodevelopmental disorders
Background:
- Preeclampsia is a serious pregnancy complication.
- Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions.
Purpose of the Study:
- To evaluate the association between preeclampsia and the risk of ASDs in children.
- To pool data from relevant case-control and cohort studies.
Main Methods:
- Comprehensive literature search of major databases (Web of Science, PubMed, Scopus) up to May 2018.
- Extraction of odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs).
- Meta-analysis to determine the pooled association.
Main Results:
- A significant association was found between preeclampsia and ASD.
- Pooled estimates indicated an increased risk: OR=1.36 (95% CI, 1.12-1.60) and RR=1.30 (95% CI, 1.20-1.41).
Conclusions:
- Preeclampsia is associated with an increased risk of ASD in children.
- Findings support a link despite existing controversy.
Purpose:
This meta-analysis pooled relevant case-control and cohort studies to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
Methods:
The search for relevant studies in major databases was performed, which included Web of Science, PubMed, and Scopus up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among the studies.
Results:
The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD (OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41).
Conclusions:
Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.
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