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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Remembering the Host in Tuberculosis Drug Development
Daniel J Frank1, David J Horne2, Noton K Dutta3
1Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
The Journal of Infectious Diseases
|December 28, 2018
Summary
New host-directed therapies (HDTs) are crucial for combating drug-resistant tuberculosis (TB). This review highlights recent advances in HDTs, focusing on novel drugs, pathways, and concepts for developing effective treatments.
Area of Science:
- Infectious Diseases
- Immunology
- Pharmacology
Background:
- Tuberculosis (TB) treatment requires new therapeutics to shorten duration and overcome drug resistance.
- Emergence of drug-resistant TB necessitates novel treatment strategies.
- Host-directed therapy (HDT) presents a promising alternative by modulating host immune responses.
Purpose of the Study:
- To review recent data on drugs, pathways, and concepts relevant to developing HDTs for TB.
- To discuss challenges and strategies for advancing HDT development.
- To highlight the importance of novel mechanisms of action against drug-resistant TB.
Main Methods:
- Literature review of recent scientific data on HDTs for TB.
- Discussion of concepts presented at the "Strategic Discussion on Repurposing Drugs & Host Directed Therapies for TB" workshop.
- Synthesis of information on drugs, pathways, and therapeutic strategies.
Main Results:
- HDTs offer novel mechanisms to activate immune defenses and reduce tissue damage.
- Repurposing existing drugs and exploring new pathways are key strategies.
- Successful HDT development requires addressing specific challenges in drug discovery and clinical application.
Conclusions:
- HDTs represent a critical new approach to combatting tuberculosis, especially drug-resistant strains.
- Further research into specific drugs, host pathways, and strategic development is essential.
- Collaboration and focused discussion, like that at the Gordon Research Conference, are vital for advancing HDT research.
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