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Immediate and short term effects of percutaneous atrial septal defect device closure on cardiac electrical remodeling

Alaa Mahmoud Roushdy1, Hebatalla Attia1, Heba Nossir1

  • 1Cardiology Department, Ain Shams University Hospital, Cairo, Egypt.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|December 29, 2018
PubMed

Insights

Device closure for atrial septal defect (ASD) rapidly improves cardiac electrical remodeling in children. Significant positive changes in P wave and QT intervals are observed within 24 hours and sustained long-term.

Area of Science:

  • Cardiology
  • Pediatric Electrophysiology

Background:

  • Atrial septal defect (ASD) is associated with electrical cardiac remodeling.
  • Device closure is a known treatment for ASD, but its immediate impact on electrical remodeling is not fully understood.

Purpose of the Study:

  • To investigate the immediate and short-term effects of percutaneous ASD device closure on cardiac electrical remodeling in pediatric patients.

Main Methods:

  • Electrocardiograms (ECG) were performed on 30 children before, and 24 hours, 1 month, and 6 months after ASD device closure.
  • Key ECG parameters including P wave and QT durations and dispersions were measured and analyzed.

Main Results:

  • Significant reductions in P wave and QT dispersions were observed as early as 24 hours post-procedure.
  • These improvements in electrical parameters continued at 1 month and were maintained at 6 months follow-up.

Conclusions:

  • Percutaneous ASD device closure rapidly reverses electrical remodeling in both atrial and ventricular myocardium.
  • The beneficial effects on cardiac electrical activity are evident within 24 hours and persist long-term.
Abstract

Keywords:
ASDDevice closureDispersionElectric remodeling

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